Fructose derivatives have great importance in food, cosmetics, and pharmaceutical industries. The derivatives such as Fructosazone, 1,2,3,4,5-O-acetyl-β-D-Fructosepyranose and D-Fructose pentabenzoate were synthesized and characterized by Melting Point, Chemical test, UV and IR. Fructosazone was prepared by the condensation of fructose with phenylhydrazine. 1,2,3,4,5-O-acetyl-β-D-fructosepyranose was prepared by acetylation of fructose with acetyl chloride in the presence of sodium acetate. D-Fructose pentabenzoate was prepared by the benzoylation of fructose with benzoyl chloride in the presence of sodium hydroxide. The percentage yields of Fructosazone, 1,2,3,4,5-Penta-O-acetyl- β -D-fructosepyranose and D-Fructose Pentacetate were 54.66%, 56.7%, and 66.28% respectively. The synthesized derivatives were characterized by performing chemical tests. Melting points were determined that showed the purity of the compound. UV/visible analysis indicated the chromophoric groups present in derivatives. IR analysis indicated the functional groups present in the synthesized derivative. The carbohydrate-derived fructose derivatives are stable and were obtained in good yield.
Fructose derivatives, condensation, acetylation, benzoylation, infrared, ultraviolet.
Sultana, T., Sarwar, Y., Rana, T., Sharif, S., Alam, S., Iqbal, M.N., Ashraf, A., Athar, A., 2019. Synthesis and Characterization of Fructose Derivatives. PSM Biol. Res., 4(3): 108-112.