Modern Stem Cell Therapy of Cardiac and Neurodegenerative Disorders: Pluses and Minuses

Author's: Muhammad Irfan, Umar Sajjad, Muhammad Naeem Iqbal
Corresponding Author: Muhammad Irfan      Email:
Article Type: Review Article     Published: Jan. 31, 2019 Pages: 51-57
DOI:        Views 524       Downloads0


Stem cell therapy is used for the treatment of many diseases like diabetes, ischemia, Parkinson’s disease, cardiac and neurodegenerative diseases. Stem cells can be differentiated into many new types as they are actually undifferentiated cells. Cardiac disease is a life-threatening disorder. Any type of injury to heart muscles increase risk factors for myocardial infarction. Studies indicate that different stem cells are used for the improvement of ventricular function by transplantation. New cardiac tissue cannot be formed but transplanted stem cells have paracrine effects that may be limited by teratoma formation. The brain has a specific formation of substitution connection to the confined and compact action of neuronal stem cells respectively. This demonstrates nervous abnormality and series of neurodegenerative infections that shows a critical civil issue of our inhabitants. So, competitive analysis is motivated using stem cell therapy as a key. Then comparisons of different studies for the treatment of different individuals who are suffering from neurodegenerative diseases are done. Different actions are taken that show aims for the charge of NP afflicted individuals. This review sums up the current scenario of stem cell therapy in Cardiac and Neurodegenerative disorders.


Stem cells, neurodegenerative pathologies, stem cell therapy, cardiac disorders.


Irfan, M., Sajjad, U., Iqbal, M.N., 2019. Modern Stem Cell Therapy of Cardiac and Neurodegenerative Disorders: Pluses and Minuses. PSM Biol. Res., 4(1): 51-57.


Ali, S., Ahmad, A., Iqbal, M.N., Muhammad, A., Irfan, M., Akhter, S.J.P.V.R., 2016. Opportunities for Stem Cells Therapy in Veterinary Medicine. PSM Vet. Res., 1(2): 60-68.

Altman, J., Das, G.D., 1965. Post-natal origin of microneurones in the rat brain. Nat., 207(5000): 953-956.

Androutsellis-Theotokis, A., Leker, R.R., Soldner, F., Hoeppner, D.J., Ravin, R., Poser, S.W., Rueger, M.A., Bae, S.-K., Kittappa, R., McKay, R.D., 2006. Notch signalling regulates stem cell numbers in vitro and in vivo. Nat., 442(7104): 823.

Baba, M., Nakajo, S., Tu, P.-H., Tomita, T., Nakaya, K., Lee, V., Trojanowski, J.Q., Iwatsubo, T., 1998. Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson’s disease and dementia with Lewy bodies. The Am. J Pathol., 152(4): 879.

Cavallucci, V., Fidaleo, M., Pani, G., 2016. Neural stem cells and nutrients: poised between quiescence and exhaustion. Trends Endocrin. Met., 27(11): 756-769.

Curtis, M.A., Low, V.F., Faull, R.L., 2012. Neurogenesis and progenitor cells in the adult human brain: a comparison between hippocampal and subventricular progenitor proliferation. Dev. Neurobiol., 72(7): 990-1005.

Doetschman, T.C., Eistetter, H., Katz, M., Schmidt, W., Kemler, R., 1985. The in vitro development of blastocyst-derived embryonic stem cell lines: formation of visceral yolk sac, blood islands and myocardium. Dev., 87(1): 27-45.

Frangogiannis, N.G., 2008. The immune system and cardiac repair. Pharmacol. Res., 58(2): 88-111.

Girlovanu, M., Susman, S., Soritau, O., Rus-Ciuca, D., Melincovici, C., Constantin, A.-M., Mihu, C.M., 2015. Stem cells-biological update and cell therapy progress. Clujul Med., 88(3): 265.

Gould, E., 2007. How widespread is adult neurogenesis in mammals? Nat. Rev. Neurosci., 8(6): 481.

Gourronc, F.A., Klingelhutz, A.J., 2012. Therapeutic opportunities: Telomere maintenance in inducible pluripotent stem cells. Mutati. Res-Fund. Mol. M., 730(1): 98-105.

Jujo, K., Ii, M., Losordo, D.W., 2008. Endothelial progenitor cells in neovascularization of infarcted myocardium. J. Mol. Cell. Cardiol., 45(4): 530-544.

Kamihata, H., Matsubara, H., Nishiue, T., Fujiyama, S., Tsutsumi, Y., Ozono, R., Masaki, H., Mori, Y., Iba, O., Tateishi, E., 2001. Implantation of bone marrow mononuclear cells into ischemic myocardium enhances collateral perfusion and regional function via side supply of angioblasts, angiogenic ligands, and cytokines. Circulation., 104(9): 1046-1052.

Karanes, C., Nelson, G.O., Chitphakdithai, P., Agura, E., Ballen, K.K., Bolan, C.D., Porter, D.L., Uberti, J.P., King, R.J., Confer, D.L., 2008. Twenty years of unrelated donor hematopoietic cell transplantation for adult recipients facilitated by the National Marrow Donor Program. Elsevier.

Kumar, A., Narayanan, K., Chaudhary, R.K., Mishra, S., Kumar, S., Vinoth, K.J., Padmanabhan, P., Gulyás, B., 2017. Current perspective of stem cell therapy in neurodegenerative and metabolic diseases. Mol. Neurobiol., 54(9): 7276-7296.

Kupatt, C., Horstkotte, J., Vlastos, G.A., Pfosser, A., Lebherz, C., Semisch, M., Thalgott, M., Büttner, K., Browarzyk, C., Mages, J.r., 2005. Embryonic endothelial progenitor cells expressing a broad range of proangiogenic and remodeling factors enhance vascularization and tissue recovery in acute and chronic ischemia. The FASEB J., 19(11): 1576-1578.

Ludolph, A.C., Bendotti, C., Blaugrund, E., Chio, A., Greensmith, L., Loeffler, J.-P., Mead, R., Niessen, H.G., Petri, S., Pradat, P.-F., 2010. Guidelines for preclinical animal research in ALS/MND: a consensus meeting. Amyotrophic Lateral Sclerosis, 11(1-2): 38-45.

Markowicz-Piasecka, M., Sikora, J., Szydłowska, A., Skupień, A., Mikiciuk-Olasik, E., Huttunen, K.M., 2017. Metformin–a future therapy for neurodegenerative diseases. Pharma. Res., 34(12): 2614-2627.

Murry, C.E., Wiseman, R.W., Schwartz, S.M., Hauschka, S.D., 1996. Skeletal myoblast transplantation for repair of myocardial necrosis. J. Clin. Invest., 98(11): 2512-2523.

Odorico, J.S., Kaufman, D.S., Thomson, J.A., 2001. Multilineage differentiation from human embryonic stem cell lines. Stem Cells., 19(3): 193-204.

Pramanik, S., Sulistio, Y.A., Heese, K., 2017. Neurotrophin signaling and stem cells—implications for neurodegenerative diseases and stem cell therapy. Mol. Neurobiol., 54(9): 7401-7459.

Quaini, F., Urbanek, K., Beltrami, A.P., Finato, N., Beltrami, C.A., Nadal-Ginard, B., Kajstura, J., Leri, A., Anversa, P., 2002. Chimerism of the transplanted heart. New Eng. J. Med., 346(1): 5-15.

Ramos, E., Egea, J., de los Ríos, C., Marco-Contelles, J., Romero, A., 2017. Melatonin as a versatile molecule to design novel multitarget hybrids against neurodegeneration. Future Med. Cem., 9(8): 765-780.

Reekmans, K., Praet, J., Daans, J., Reumers, V., Pauwels, P., Van der Linden, A., Berneman, Z.N., Ponsaerts, P., 2012. Current challenges for the advancement of neural stem cell biology and transplantation research. Stem Cell Rev. Rep., 8(1): 262-278.

Reinecke, H., Poppa, V., Murry, C.E., 2002. Skeletal muscle stem cells do not transdifferentiate into cardiomyocytes after cardiac grafting. J. Mol. Cell. Cardiol., 34(2): 241-249.

Ryzhov, S., Solenkova, N.V., Goldstein, A.E., Lamparter, M., Fleenor, T., Young, P.P., Greelish, J.P., Byrne, J.G., Vaughan, D.E., Biaggioni, I., 2008. Adenosine receptor–mediated adhesion of endothelial progenitors to cardiac microvascular endothelial cells. Circulation Res., 102(3): 356-363.

Tomita, S., Li, R.-K., Weisel, R.D., Mickle, D.A., Kim, E.-J., Sakai, T., Jia, Z.-Q., 1999. Autologous transplantation of bone marrow cells improves damaged heart function. Circulation., 100(suppl 2): II-247-Ii-256.

Tuch, B.E., 2006. Stem cells: a clinical update. Australian family physician, 35(9): 719.

Vasa, M., Fichtlscherer, S., Aicher, A., Adler, K., Urbich, C., Martin, H., Zeiher, A.M., Dimmeler, S., 2001. Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease. Circulation Res., 89(1): e1-e7.

Wiatr, K., Szlachcic, W.J., Trzeciak, M., Figlerowicz, M., Figiel, M., 2018. Huntington disease as a neurodevelopmental disorder and early signs of the disease in stem cells. Mol. Neurobiol., 55(4): 3351-3371.

Zhang, G., Hu, Q., Braunlin, E.A., Suggs, L.J., Zhang, J., 2008. Enhancing efficacy of stem cell transplantation to the heart with a PEGylated fibrin biomatrix. Tissue Engineering Part A, 14(6): 1025-1036.

Zhao, C., Deng, W., Gage, F.H., 2008. Mechanisms and functional implications of adult neurogenesis. Cell., 132(4): 645-660.