Ceftazidime Resistant Bacteria in Clinical Samples: Do We Need New Antibiotics?

Author's: Muhammad Naeem Iqbal, Asfa Ashraf
Authors' Affiliations
Article Type: Editorial     Published: Oct. 28, 2018 Pages: 58-59
DOI:        Views 1770       Downloads 0


Antibiotic resistant strains and species referred to as ‘’super bugs’’ contribute to emergence of disease. Antibiotic resistant bacterial infections have become a threat, in particular in developing countries. Incidence and mortality from infectious diseases have increased during the past decade. Antibiotic resistance causes biological cost by reducing fitness of resistant strains, which can minimize the spread of resistant bacteria. Additional mutations also aid in the survival of resistant bacteria (Topp et al., 2013). Microbes that are resistant to multiple antimicrobials are called multidrug resistant (MDR) (Iqbal et al., 2015a). Antibiotics are among the most commonly prescribed drugs in hospitals and in developed countries about 30% of the hospitalized patients are treated with these drugs (Shankar et al., 2003).

In this issue, Saleem et al. report the Ceftazidime resistance in clinical isolates of bacteria. The proportions of resistant isolates to Ceftazidime ranged E.coli 56.31%, Staphylococcus aureus 6.84%, Pseudomonas aeruginosa 4.21%, Klebsiella 1.57%, and Proteus sp. 1.05%. Our data showed that female patients had the highest level of resistant bacteria compared to males. That significantly more resistant bacteria were found in female clinical samples correlates with a higher susceptibility of infection in females than males, due to the physiological and anatomical differences.

Ceftazidime is a third-generation cephalosporin that was introduced into clinical use in the 1980s because of its verified broad spectrum activity against Gram-positive cocci and Gram-negative bacilli, including Pseudomonas aeruginosa (Turner, 2009). The emergence of Ceftazidime-resistant bacteria must be considered one of the most frightening consequences of microbial evolution in the last 2 decades. The physicians prescribe broad spectrum antibiotics without antibiotic susceptibility test. There is no systematic national surveillance of antibiotic resistance and insufficient data is available to quantify the problem (Abdul et al., 2008). Resistance to Ceftazidime demonstrated that more consumption of a specific antibiotic leads to sustainability of resistance against it. These resistant isolates can be further studied in terms of their multidrug resistance and resistance to other antibiotics to find a suitable antibiotic or combinations of antibiotics for the treatment of infectious diseases. Plant derived products can be tested to determine antibacterial activity (Hussain et al., 2016; Iqbal et al., 2015b; Shahzad et al., 2017) that can be used to treat infectious diseases.

Although well conducted, there are some limitations to the present work. The molecular methods can be employed to detect antibiotic resistance. Moreover, the types of bacteria tested were limited to 5 strains. More attention is needed to recognize and measure trends in resistance internally. There is an immediate need to step out and control these pathogenic infections and lest effectiveness of antibiotics.




Authors declare that there is no conflict of interest.


Abdul, J.K.P., Abdul, R.K., Abdul, H.Y.S., Sanaullah, K., 2008. Current antibiotic susceptibility in Khyber Teaching Hospital Peshawar Pakistan.  J. Res. 13, 224-229.

Hussain, F., Kalim, M., Ali, H., Ali, T., Khan, M., Xiao, S., Iqbal, M.N., Ashraf, A., 2016. Antibacterial Activities of Methanolic Extracts of Datura inoxia. PSM Microbiol., 01(1): 33-35.

Iqbal, M.N., Anjum, A.A., Ali, M.A., Hussain, F., Ali, S., Muhammad, A., Irfan, M., Ahmad, A., Irfan, M., Shabbir, A., 2015b. Assessment of microbial load of un-pasteurized fruit juices and in vitro antibacterial potential of honey against bacterial isolates. Open Microbiol. J., 9: 26-32.

Iqbal, M.N., Anjum, A.A., Ali, M.A., Wang, S., Ali, S., Muhammad, A., Irfan, M., Ahmad, A., Shabbir, A., 2015a. Characterization of Multidrug-Resistant Bacteria from Packed Fruit Juices Sold in Lahore City. 4th International Molecular Biology and Biotechnology Congress and Conference on Life Sciences  Research  2015, At Al-Nafees Medical College and Hospital, Isra University, Islamabad Pakistan, Volume: 4.

Saleem, M., Batool, A., Iqbal, M.N, Ashraf, A., 2018. Characterization of Ceftazidime Resistance in Clinical Isolates of Bacteria in Lahore, Pakistan. Int. J. Mol. Microbiol., 1(2): 44-50.

Shahzad, M.I., Ashraf, H., Iqbal, M.N., Khanum, A., 2017. Medicinal Evaluation of Common Plants against Mouth Microflora. PSM Microbiol., 2(2): 34-40.

Shankar, R.P., Partha, P., Shenoy, N.K., Easow, J.H., Brahmadathan, K.N., 2003. Prescribing patterns of antibiotics and sensitivity patterns of common microorganisms in the Internal Medicine ward of a teaching hospital in Western Nepal: a prospective study. Ann. Clin. Microbiol. Antimicrob., 2:7.

Topp, E., Chapman, R., Devers, L. M., Hartmann, A., Marti, R., Martin, L.F., Sabourin, L., Scott, A., Sumarah, M., 2013. Accelerated Biodegradation of Veterinary Antibiotics in Agricultural Soil following Long-Term Exposure, and Isolation of a Sulfamethazine-degrading sp. J. Environ. Qual., 42 (1): 173–178.

Turner, P.J., 2009. Activity of meropenem and other broad-spectrum agents against nosocomial isolates. Diagn. Microbiol. Infect. Dis., 63(2): 217-222.