A Review of Biological Activities of Genus Croton

Author's: Ibrahim Ali Al-Hakami1, Salwa Raweh1, Amina El-Shaibany1, Abdulrahman Humaid2,3*, Mahmoud Elaasser4
Authors' Affiliations
1Pharmacognosy Department, Pharmacy College, Sana`a University, Sanaa, Yemen.2Department of Biology, Faculty of Science, Sana`a University, Sanaa, Yemen.3Department of Pharmacy, Faculty of Medical Science, Modern Science University, Sana`a, Yemen.4The Regional Center for Mycology and Biotechnology, Al-Azhar University, 11787, Nasr City, Cairo, Egypt.
*CorrespondenceAbdulrahman HumaidEmail:humaidyemen@yahoo.com
Article Type: Mini-Review     Published: Mar. 08, 2022 Pages: 12-18
DOI:        Views 516       Downloads 0


Croton contains a wide range of constituents, including phorbol esters, alkaloids, di and triterpenoids such as clerodane, uphold derivatives, and flavonoids and their glycosides, all of which have medicinal value. In addition, several Croton species have a red sap, which contains proanthocyanins and/or alkaloids in some species. Some species are aromatic because they contain volatile oil. The current review summarizes the most important biological activities of Croton species for future research as potential medicines. It is important to note that the presence of secondary metabolite classes in Croton is a point worth considering because it could lead to the discovery of pharmacologically active substances.


Biological activities,

Pharmacology of Croton,


Potential medicines.

Authors’ Contribution

AE conceived and designed the study; IAA, ME, and SR wrote, revised the paper. AE and AH gave final approval for publication of the paper.

How to cite

Al-Hakami, I.A., Raweh, S., El-Shaibany, A., Humaid, A., Elaasser, M., 2022. A Review of Biological Activities of Genus Croton. PSM Microbiol., 7(1): 12-18.


Abera, A., Lemessa, F., Muleta, D., 2011. The antifungal activity of some medicinal plants against coffee berry disease caused by Colletotrichum kahawae. Int. J. Agric. Res., 6(3): 268-279.

Abera, A., Lemessa, F., Muleta, D., 2011. The antifungal activity of some medicinal plants against coffee berry disease caused by Colletotrichum kahawae. Int. J. Agric. Res., 6(3): 268-279.

Abi Beaulah, G., Jaya Santhi, R., Mohamed Sadiq, A., 2013. In vitro antifungal activities of Croton sparsiflorus. J. Chem. Pharm. Res., 5: 136-141.

Ali, N.M., Annegowda, H., Mansor, S., Ismail, S., Ramanathan, S., Mordi, M., 2012. Phytochemical screening, antioxidant and analgesic activities of Croton argyratus ethanolic extracts. J. Medic. Plants Res., 6(21): 3724-3731.

Amjad, S., Saleem, M., Ashraf, A., Iqbal, M.N., 2020. Prevalence of Cancer Types in Patients attending Mayo Hospital Lahore, Pakistan. Int. J. Molec. Microbiol., 3(2): 25-34.

Ashraf, A., Ali, M.A., Iqbal, M.N., 2020. Monolluma quadrangula as the Protective and Curative Plant against Diabetes Mellitus. PSM Microbiol., 5(3): 89-91.

Ashraf, A., Xiong, X., Iqbal, M.N., Lin, Y., 2018. BRCA Mutations and Survival Outcome in Young-onset Breast Cancer. Int. J. Molec. Microbiol., 1(2): 56-57.

Bayor, M., Gbedema, S., Annan, K., 2009. Croton membranaceus used in herbal formulations for measles in Ghana has potent antimicrobial properties. J. Pharmacog. Phytother., 1(4): 47-51.

Biscaro, F., Parisotto, E.B., Zanette, V.C., Günther, T.M.F., Ferreira, E.A., Gris, E.F., Correia, J.F.G., Pich, C.T., Mattivi, F., Filho, D.W., 2013. Anticancer activity of flavonol and flavan-3-ol rich extracts from Croton celtidifolius latex. Pharmac. Biol., 51(6): 737-743.

Caruzo, M.B., van Ee, B.W., Cordeiro, I., Berry, P.E., Riina, R., 2011. Molecular phylogenetics and character evolution of the “sacaca” clade: novel relationships of Croton section Cleodora (Euphorbiaceae). Mol. Phylogenet. Evol., 60(2): 193-206.

Dey, T., Saha, S., Adhikari, S., Ghosh, P., 2015. A Comprehensive Review on Medicinally Important Plant, Croton tiglium L. Int. J. Current Res. Bioscie. Plant Biol., 2(7): 124-128.

Din, M., Hafeez, M., Iqbal, M.N., Ashraf, A., Alam, S., Masood, S., 2016. Parameters of Radiotherapy Techniques in Early Breast Cancer. PSM Microbiol., 1(2): 66-71.

Ghosh, A., Saha, B., Das, J., Ghosh, P., 2014. Phytochemical investigation of the toluene extract of the root of Croton bonplandianum Bail.

Habtom, S., Gebrehiwot, S., 2019. In vitro antimicrobial activities of crude extracts of Vernonia amygdalina and Croton macrostachyus against some bacterial and fungal test pathogens. J. Phytopharmacol., 8(2): 57-62.

Iqbal, M.N., 2021a. Blood Cancer Awareness: Current and Future Approaches to Lymphoma Management. PSM Microbiol., 6(3): 92-94.

Iqbal, M.N., 2021b. Breast Cancer Awareness: Current Trends and Future Approaches to Breast Cancer Management. PSM Biol. Res., 6(4): 133-135.

Iqbal, M.N., Ashraf, A., 2018. Recombinant Protein Production in Plants: Biofactories for Therapeutics. Int. J. Molec. Microbiol., 1(1): 38-39.

Iraqui, P., Yadav, R., 2015. Evaluation of antibacterial and antifungal activities of leaf and seed extracts of Croton tiglium plant against skin disease causing microbes. Int. J. Res. Studies in Bioscie., 3(5): 139-144.

Irfan, M., Sughra, K., Iqbal, M.N., Mehmood, S., Shaheen, A., Anwar, Z., 2016. Arresting Cancer Progression by VEGF Inhibitions: An Update. PSM Microbiol., 1(2): 72-78.

Kim, J.H., Lee, S.J., Han, Y.B., Moon, J.J., Kim, J.B., 1994. Isolation of isoguanosine from Croton tiglium and its antitumor activity. Arch. Pharmacal Res., 17(2): 115-118.

Lahlou, S., Leal-Cardoso, J.H., Magalhães, P.J.C., 2000. Essential oil of Croton nepetaefolius decreases blood pressure through an action upon vascular smooth muscle: studies in DOCA-salt hypertensive rats. Planta Med., 66(02): 138-143.

Lokendrajit, N., Indira, S., Swapana, N., Singh, C., 2012. Antioxidant and Antimicrobial activity of Croton caudatus Geisel. Asian J. Chem., 24(10).

Magalhães, P., Criddle, D., Tavares, R., 1998. Effects of Croton nepetaefolius on intestinal smooth muscle. Phytother. Res., 12: 172-177.

McChesney, J.D., Clark, A.M., Silveira, E.R., 1991. Antimicrobial diterpenes of Croton sonderianus. II. ent-Beyer-15-en-18-oic acid. Pharm. Res., 8(10): 1243-1247.

Miller, A.G., Morris, M., 2004. Ethnoflora of the Soqotra Archipelago. Royal Botanic Garden Edinburgh.

Morais, S.M.d., Catunda Júnior, F.E.A., Silva, A.R.A.d., Martins Neto, J.S., Rondina, D., Cardoso, J.H.L., 2006. Antioxidant activity of essential oils from Northeastern Brazilian Croton species. Quim. Nova., 29(5): 907-910.

Mulcahy, N., 2008. Cancer to become leading cause of death worldwide by 2010. Medscape Medical News.

Nardi, G., Felippi, R., DalBó, S., Siqueira-Junior, J.M., Arruda, D., Monache, F., Timbola, A.K., Pizzolatti, M., Ckless, K., Ribeiro-do-Valle, R.M., 2003. Anti-inflammatory and antioxidant effects of Croton celtidifolius Bark. Phytomedicine: Int. J. Phytother. Phytopharmacol., 10: 176-84.

Ndunda, B., 2014. Phytochemistry and bioactivity investigations of three Kenyan croton species, University of Nairobi.

Peres, M.T., Delle Monache, F., Cruz, A.B., Pizzolatti, M.G., Yunes, R.A., 1997. Chemical composition and antimicrobial activity of Croton urucurana Baillon (Euphorbiaceae). J. Ethnopharmacol., 56(3): 223-6.

Rahim, S., Almagboul, A., Mohammed, N., 2016. Antimicrobial activity of Croton zambesicus, Acacia ehrenbergiana and Fagonia cretica. National J. Adv. Res., 2(3): 16-20.

Richardson, A., King, K., 2011. Plants of Deep South Texas: a field guide to the woody and flowering species. Texas A&M University Press.

Roengsumran, S., Musikul, K., Petsom, A., Vilaivan, T., Sangvanich, P., Pornpakakul, S., Puthong, S., Chaichantipyuth, C., Jaiboon, N., Chaichit, N., 2002. Croblongifolin, a new anticancer clerodane from Croton oblongifolius. Planta Med., 68(03): 274-277.

Roengsumran, S., Petsom, A., Kuptiyanuwat, N., Vilaivan, T., Ngamrojnavanich, N., Chaichantipyuth, C., Phuthong, S., 2001. Cytotoxic labdane diterpenoids from Croton oblongifolius. Phytochem., 56(1): 103-107.

Ruan, W.-j., Lai, M.-d., Zhou, J.-g., 2006. Anticancer effects of Chinese herbal medicine, science or myth? J. Zhejiang Univ. Sci. B., 7(12): 1006-1014.

Salatino, A., Salatino, M.L.F., Negri, G., 2007. Traditional uses, chemistry and pharmacology of Croton species (Euphorbiaceae). J. Braz. Chem. Soc., 18(1): 11-33.

Sandoval, M., Okuhama, N.N., Clark, M., Angeles, F.M., Lao, J., Bustamante, S., Miller, M.J., 2002. Sangre de grado Croton palanostigma induces apoptosis in human gastrointestinal cancer cells. J. Ethnopharmacol., 80(2-3): 121-129.

Shahid, M., Tayyab, M., Naz, F., Jamil, A., Ashraf, M., Gilani, A.H., 2008. Activity‐guided isolation of a novel protein from Croton tiglium with antifungal and antibacterial activities. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 22(12): 1646-1649.

Shahzad, M.I., Ashraf, H., Iqbal, M.N., Khanum, A., 2017. Medicinal Evaluation of Common Plants against Mouth Microflora. PSM Microbiol., 2(2): 34-40.

Simionatto, E., Bonani, V.F., Morel, A.F., Poppi, N.R., Raposo Júnior, J.L., Stuker, C.Z., Peruzzo, G.M., Peres, M.T., Hess, S.C., 2007. Chemical composition and evaluation of antibacterial and antioxidant activities of the essential oil of Croton urucurana Baillon (Euphorbiaceae) stem bark. J. Braz. Chem. Soc., 18(5): 879-885.

SL D, K.S., Baviskar, B., Khangenbam, R., Koli, U., Daga, N., Gadbail, P., Jain, P., 2009. In vitro antioxidant activity and phenolic content of Croton caudatum. vitro, 1(2): 174-6.

Tene, M., Ndontsa, B.L., Tane, P., de Dieu Tamokou, J., Kuiate, J.-R., 2009. Antimicrobial diterpenoids and triterpenoids from the stem bark of Croton macrostachys. Int. J. Biol. Chem. Sci., 3(3).

Torrico, F., Cepeda, M., Guerrero, G., Melendez, F., Blanco, Z., Canelón, D.J., Diaz, B., Compagnone, R.S., Suárez, A.I., 2007. Hypoglycaemic effect of Croton cuneatus in streptozotocin-induced diabetic rats. Revista Brasileira de Farmacognosia, 17: 166-169.

Ullah, M., Zaynab, M., Fatima, M., Abbas, S., Sharif, Y., Farooq, T.H., Zaffar, M.H., Ullah, R., Khan, S.U., Hussain, W., Ullah, I., Shaheen, S., Ali, M., 2018. Plants as Antidiabetic Agents: Traditional Knowledge to Pharmacological Validation. PSM Biol. Res., 3(3): 111-119.

Zahid, K., Mughal, T., 2019. Evaluation of Antifungal Activity of Nine Members of Family Euphorbiaceae of Lahore Region against Aspergillus niger, Rhizopus oryzae & Alternaria solani. Am. J. Biomed. Sci. Res., 6(3): 205-208.

Zaynab, M., Fatima, M., Abbas, S., Sharif, Y., Jamil, K., Ashraf, A., Aslam, M.M., Shabbir, A., Batool, W., 2018. Proteomics Approach Reveals Importance of Herbal Plants in Curing Diseases. Int. J. Molec. Microbiol., 1(1): 23-28.