A Comparative Study to Assess the Quality of Different Marketed Brands of Metformin HCl

Author's: Anass A. Alnedhary1, Abdualqawi A. Numan2,3, Mahfoudh M. AL-Hammadi4, Fatima A. Murshed4*, Huda M. Dubais5
Authors' Affiliations
1Chemistry Department, Faculty of Education, Khawlan Branch, Sana'a University, Sana'a, Yemen.2Sana'a University, Faculty of Education, Department of Science Curricula and Teaching Methodologies, Yemen.3Al-janad University for Science and Technology, Faculty of Medical Sciences, Department of Pharmacy, Yemen.4Chemistry Department, Faculty of Science, Sana'a University, Sana'a, Yemen.5Pharmaceutical Science Department, Faculty of Pharmacy, University of Science and Technology, Sana'a, Yemen.*CorrespondenceFatima A. MurshedEmail:fatima.murshed2018@gmail.com
Article Type: Research Article     Published: Jul. 04, 2021 Pages: 84-95
DOI:        Views 131       Downloads 0

Abstract

The present work reported quality assessments and stability studies of metformin hydrochloride in various brands with a label claim of 500 mg marketed in the capital Sana’a, Yemen. Physical parameters including thickness, diameter, hardness, friability, weight variation, and disintegration time were evaluated.  Assay tests and dissolution rates were carried out using HPLC-UV and spectrophotometric methods respectively. All investigations were done at purchase time and after one month, three months, and six months storage conditions under an accelerated stability environment (40±2°C and 75±5% RH). The results showed that all brands of metformin hydrochloride complied with the official specification for thickness, diameter, hardness, friability, weight variation, disintegration time, dissolution, and assay tests.  Assay evaluation results revealed that all tested brands have met the acceptance criteria (95%-105%) with exception of ME1 samples stored for three months whose values (94.29%) were lower than the acceptable limit and ME4 (105.95%) and ME5 (105.66%) stored for one month that was higher than the acceptable range.

Keywords

Metformin HCl,

Stability studies,

HPLC, Spectrophotometry.

Authors’ Contribution

AAA conceived and designed the study. FAM performed the assay test with HPLC, and HMD studied the physical properties and UV experiments. AAN and MMA analyzed data, wrote and revised the paper.

How to cite

Alnedhary, A.A., Numan, A.A., AL-Hammadi, M.M., Murshed, F.A., Dubais, H.M., 2021. A Comparative Study to Assess the Quality of Different Marketed Brands of Metformin HCl. PSM Biol. Res., 6(3): 84-95.


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