Diabetes is the most devastating and serious metabolic disease. The available natural remedies are considered valuable source of therapeutic agents. A scientific validation of the reported antidiabetic plants on the basis of their traditional use may pave the way for the development of novel and effective antidiabetic drugs. Such approaches are the necessity of the day because the available medicines are insufficient to manage all consequences of diabetes, and the economic problems and shortage of current therapies in most developing countries. This review comprises information of 184 antidiabetic medicinal plants of Pakistan with respect to traditional knowledge. The manuscript also includes the in-vitro or in-vivo potential, toxicity, mode of action, and perspective for future research. This effort may serve as leading point for formulation of novel herbal mixtures, development of antidiabetic drugs or precursors.
Antidiabetic medicinal plants; traditional knowledge; pharmacological validation.
Ullah, M., Zaynab, M., Fatima, M., Abbas, S., Sharif, Y., Farooq, T.H., Zaffar, M.H., Ullah, R., Khan, S. U., Hussain, W., Ullah, I., Shaheen, S., Ali, M., 2018. Plants as Antidiabetic Agents: Traditional Knowledge to Pharmacological Validation. PSM Biol. Res., 3(3): BR-2018-022.